
W-7 HCl
CAS No. 61714-27-0
W-7 HCl( W-7 hydrochloride | W-7 hydrochloride | W-7 hydrochloride | W-7 HCl | W 7 HCl | W7 HCl )
Catalog No. M24618 CAS No. 61714-27-0
W-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
10MG | 27 | In Stock |
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25MG | 58 | In Stock |
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100MG | Get Quote | In Stock |
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Biological Information
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Product NameW-7 HCl
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NoteResearch use only, not for human use.
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Brief DescriptionW-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity
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DescriptionW-7 HCl, a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
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In VitroW-7 is distributed mainly in the cytoplasm, and inhibits proliferation of Chinese hamster ovary K1 (CHO-K1) cells. W-7 selectively blocks the phase of the cell cycle (G1/S boundary phase) in a manner. 25 μM W-7 arrests the growth of the cells at the G1/S boundary phase of the cell cycle.W-7 (100 μM) exhibits a similar extent of antagonism between the contractile responses to carbachol and KCl. The increase in myosin light chain (P-LC) phosphate content in response to 1-min stimulation with 10 μM carbachol is inhibited by W-7. W-7 antagonizes the smooth muscle contraction through the inhibition of the initial increase in the P-LC phosphorylation.Treatment with W-7 results in the dose-dependent inhibition of cell proliferation in various human multiple myeloma cell lines. W-7induces G1 phase cell cycle arrest by downregulating cyclins and upregulating p21cip1. W-7 induces apoptosis via caspase activation; this occurred partly through the elevation of intracellular calcium levels and mitochondrial membrane potential depolarization and through inhibition of the STAT3 phosphorylation and subsequent downregulation of Mcl-1 protein. W-7 competitively inhibits Ca2+/calmodulin-dependent phosphodiesterase with a Ki value of 300 μM.
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In VivoW-7 (3 mg/kg; intraperitoneal injection; on 5 consecutive days per week; female BALB/c nu mice) treatment significantly reduces tumor growth in a murine MM model. Animal Model:Female BALB/c nu mice (6-week-old) injected with RPMI 8226 cells Dosage:3 mg/kg Administration:Intraperitoneal injection; on 5 consecutive days per week Result:Significantly reduced tumor growth in a murine MM model.
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SynonymsW-7 hydrochloride | W-7 hydrochloride | W-7 hydrochloride | W-7 HCl | W 7 HCl | W7 HCl
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PathwayEndocrinology/Hormones
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TargetCaMK
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Recptorcalmodulin|apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number61714-27-0
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Formula Weight377.32
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Molecular FormulaC16H22Cl2N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL?(662.55 mM;?Need ultrasonic)
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SMILESC1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCCCN.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Celotto AC, Capellini VK, Restini CB, Baldo CF, Bendhack LM, Evora PR. Extracellular alkalinization induces endothelium-derived nitric oxide dependent relaxation in rat thoracic aorta. Nitric Oxide. 2010 Dec 15;23(4):269-74. doi: 10.1016/j.niox.2010.07.008. Epub 2010 Aug 1. PubMed PMID: 20682356.
molnova catalog



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